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Description

  • GeneName: IDH2; IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH.
  • SynName: isocitrate dehydrogenase 2 (NADP+); mitochondrial; D2HGA2 antibody; ICD-M antibody.
  • IDH antibody; IDHM antibody; IDP antibody; IDPM antibody; mNADP-IDH antibody; IDH2 antibody.
  • Tested: Immunohistochemistry (IHC) Paraffin, Western Blot (WB).
  • Form: Liquid; *Purity: Purified by antigen-affinity chromatography.; *Conc: 1 mg/ml.
  • Cellular Localization: Mitochondrion.
  • Storage Buffer: 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative..
  • Predicted Target Size: 51 kDa; *Positive Controls: Jurkat.
  • Antigen Species: Human.
  • FREE-8GB-USBDrive for this item. Item is for research use. NOT for diagnostic/therapeutic procedure..
  • Imported from USA.
*Clonality: Polyclonal; *Source: Rabbit; *Reactivity: Human Predicted Reactivity: Rhesus Monkey (100%); *AppNotes: IHC (Formalin-fixed paraffin-embedded sections): 1:100-1:1000 Western blot: 1:500-1:3000 IHC (Formalin-fixed paraffin-embedded sections): suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) Optimal dilutions/concentrations should be determined by the researcher.; *Immunogen: Recombinant fragment corresponding to a region within amino acids 2 and 214 of IDH2 (Uniprot ID#P48735); *Research Area: Cancer; Type of cancer; Brain; Glioma; Metabolism; Carbonhydrate metabolism; Kreb Cycle; *Storage: Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.; *Accession#: NP_002159; NM_002168; P48735; *Description: Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq]Product Description: Rabbit Polyclonal antibody to IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial); *NCBI Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the...
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IDH2 antibody [N1N3] (Antibody)

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1

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