

🧠 Elevate your wellness game with science-backed methylation mastery!
THORNE Methyl-Guard Plus delivers active folate (5-MTHF) alongside methylcobalamin B12 and essential B vitamins to support healthy methylation and maintain optimal homocysteine levels. This gluten, dairy, and soy-free formula is rigorously tested in four stages for purity and potency, trusted by elite athletes and healthcare professionals alike to promote cardiovascular and brain health.


















| ASIN | B00O5AHC4S |
| Best Sellers Rank | #5,774 in Health & Household ( See Top 100 in Health & Household ) #108 in Blended Vitamin & Mineral Supplements #585 in Diet & Sports Nutrition |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,699) |
| Date First Available | March 8, 2011 |
| Department | All Ages |
| Is Discontinued By Manufacturer | No |
| Item model number | No Model |
| Manufacturer | Thorne Research |
| Product Dimensions | 2.38 x 2.38 x 4.23 inches; 3.84 ounces |
J**N
MTHFR
High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.
A**N
Love!
Love! It’s high quality, easy to take, and has really helped lower my homocysteine levels as recommended by my doctor. I appreciate that it uses active forms of B vitamins like 5-MTHF for better absorption. Thorne is such a trusted, clean brand, which gives me extra confidence in what I’m taking. I feel more balanced and energized since adding it to my routine—definitely a product I’ll keep using!
G**D
Dr recommended.
Dr recommended for my MTHFR gene mutation. No odor, not taste, no after taste. No stomach issues. Hope to see the benefit in raising my folate and lowering my homocysteine and thereby lowering a risk of heart attack. .
I**8
Great product with reputable quality ingredients
I'm a big believer in investing in high-quality supplements, and Thorne Research is one of the brands I trust most. Their Methyl-Guard Plus is a great option for anyone looking to support their methylation pathways, especially if they have the MTHFR gene mutation. I've been using Methyl-Guard Plus for a few months now, and I've noticed a significant improvement in my energy levels and overall well-being. I also appreciate that it doesn't cause any stomach upset, which is a common problem with other B-vitamin supplements. If you're looking for a high-quality, effective B-vitamin supplement, I highly recommend Thorne Research's Methyl-Guard Plus.
B**Z
Love Thorne products
I bought these after learning that we may be vitamin deficient due to not metabolizing well. I love that Thorne offers this for exactly that! I trust the Thorne brand and look forward to better mental health outcomes!
J**T
Good product but will change color
I’ve been taking this for almost a yr or maybe 9 mos per my Dr. it has been confusing at times as I fill a weekly box with my supplimants for each day as I take quite a few. I’ve noticed that the capsules turn really dark after being in the box. At first I was sure it was turmeric as I had filled capsules with turmeric and I’m afraid I may have thrown some away which this are way to pricy to throw away. I’ve just recently realized they are changing colors as I knew absolutely I did not put the wrong thing in. I wish the manufacturer would address this as to wheather it affects the potency. Surely it doesn’t. Either way just a heads up that they will change from light to a dark burnt Orange. As long as mine are in the original bottle they stay same. Otherwise I have no complaints.
C**S
Thorne
They are really easy to swallow
D**N
a great product
Heard about this product from my doctor
L**.
Recently I found out I’m anemic and distant to go on medication so I did my research and found this to have all the things I need.
J**N
Only 5 days of taking it but I feel like it’s doing me good
M**R
good product
R**.
Good to take supplements, still cannot see the justification of this high price!
Trustpilot
1 day ago
2 weeks ago