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🛡️ Stay ahead of pests with Frontline Plus — because your dog deserves the best defense!
Frontline Plus Flea and Tick Treatment offers fast-acting, waterproof protection for extra-large dogs (89-132 lbs) with a single monthly topical dose. Formulated with fipronil and (S)-methoprene, it kills fleas, flea eggs, larvae, chewing lice, and ticks that transmit Lyme disease. Trusted by pet owners for over 20 years, it continuously replenishes through sebaceous glands, ensuring 30 days of reliable defense even if your dog gets wet. The package includes 3 easy-to-apply treatments designed for all life stages, making it the go-to solution for comprehensive flea and tick control.

















| ASIN | B0002J1FP8 |
| Active Ingredients | fipronil and (S)-methoprene |
| Age Range Description | All Life Stages |
| Allergen Information | Abalone Free |
| Brand Name | Frontline |
| Customer Reviews | 4.4 4.4 out of 5 stars (11,141) |
| Global Trade Identification Number | 00350604287308 |
| Included Components | Package includes 3 applicators |
| Item Form | Stick |
| Item Type Name | Topical Red box |
| Item Weight | 1.6 Ounces |
| Manufacturer | Frontline |
| Manufacturer Part Number | 72220 |
| Model Number | 72220 |
| Scent Name | Unscented |
| Target Species | Dog |
| Unit Count | 1 Count |
| Volume | 302.4 Milliliters |
T**E
I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on Amazon! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!
S**H
Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...
L**L
Great product, works well.
D**S
Fantastic for feather and leg mites in chickens, scales start falling off within days, can take a few treatments for bad infestations. Slather with neem oil also to suffocate the mites between treatments. A lot of vets recommend this off label for mange in goats, swine and camelids and it works wonderfully. Treat, then treat again in 2-4 weeks. Hair starts growing back within a few days. In 2 weeks you can hardly tell but treat again or the mites come back since the eggs are hatching- get them on a mineral buffet as well so they can balance their systems and immunity to pests. However it is not lasting the 30 days it used to for fleas in dogs. Fleas were gone for about a week after treatment. Then one or 2 started appearing again. I am going to treat dogs for fleas every 2 weeks.This is the reason for 4 stars. I buy this plus size to treat 4 small 25lb dogs. It works great for chicken leg mites and feather mites, youtube videos show you how to apply, a drop on each leg, around vent, back of neck etc. Fantastic for mange in goats and llamas- use the same weight used for a dog.
A**O
excellent product
Trustpilot
3 weeks ago
1 month ago