

✨ Clear skin, no compromises — glow up with Differin! 💫
Differin Acne Treatment Gel features 0.1% adapalene, the first FDA-approved OTC retinoid acne treatment in over 30 years. This water-based, non-comedogenic formula penetrates deep into pores to clear, treat, and prevent acne by normalizing skin cell turnover and reducing inflammation. Clinically proven to reduce acne breakouts by up to 87% in 12 weeks, it’s gentle enough for sensitive skin and designed for easy daily use, making it a must-have for anyone serious about clear, healthy skin.















| ASIN | B07ZTMXJVK |
| Customer Reviews | 4.4 4.4 out of 5 stars (7,944) |
| Department | Beauty & Personal Care |
| Item model number | 0299.491010 |
| Manufacturer | Galderma Laboratories, Inc |
| Product Dimensions | 1.6 x 2.65 x 6.28 inches; 1.76 ounces |
| UPC | 302994910106 |
A**R
Highly Effective, Gentle, and Worth It for Acne-Prone Skin
This acne treatment gel is one of the best skincare products I've used. It’s powerful yet gentle, and it really delivers on clearing breakouts and preventing new ones. 🔹 Clears Acne & Helps Prevent New Breakouts It works deep into pores to target acne at the source — rather than just drying out existing pimples, it helps stop new ones from forming. After a few weeks of use, I noticed fewer breakouts and smoother skin overall. 🔹 Gentle Enough for Sensitive Skin Even though it’s a retinoid and highly effective, the formula is water-based, oil-free, and non-comedogenic. It didn’t irritate my skin or cause excessive dryness — you get the power of a prescription-strength product with a surprisingly gentle finish. 🔹 Improves Skin Texture and Reduces Acne Marks Over time, my skin tone looked more even, and old blemishes faded faster. It not only treats active acne but also helps with discoloration and overall smoothness. 🔹 Easy Daily Use & Real Results It integrates easily into a nightly skincare routine. Once applied, it absorbs quickly and layers well under moisturizer. Within a few weeks, skin felt clearer and healthier — you can actually see the difference on breakouts, tone, and texture. ✅ Pros: Powerful acne treatment that works deep in pores Helps prevent future breakouts instead of just treating existing ones Gentle enough for sensitive/acne-prone skin Improves skin texture and marks over time Easy to use daily and delivers real results ❌ Cons (minor): Skin may feel slightly dry at first — best to pair with a good moisturizer Overall: If you struggle with acne or frequent breakouts, this gel is a game-changer. Effective, gentle, and noticeable results — a solid 5-star product that I’d recommend without hesitation.
J**T
Works great for my daughter
This acne treatment has worked really well for my daughter. After consistent use, we noticed a clear improvement in her skin—fewer breakouts and less inflammation. It’s gentle enough for her sensitive skin and didn’t cause excessive irritation when used as directed. The gel is easy to apply, absorbs quickly, and a small amount goes a long way. We started slowly and paired it with a good moisturizer, which helped minimize dryness. Over time, her skin became more balanced and clearer. Overall, this has been an effective and reliable acne treatment for my daughter. We’re very happy with the results.
M**Z
keeps acne away
i’ve been using this for about two years. i used isotrerinon ( accutane) in the past and i feel like this help keeps the acne away.
C**.
It works well!
I feel like this works some times. In not sure what kind of acne I have but I get different types of white heads black head. And I have T zone oily skin. It works on some break outs but not all my breakouts. I still really like it a lot and use it often.
M**.
1MO. & 90% MASKNE FREE!
THE PURGE IS REAL! I am 41 years old, and seem to have suffered from late-onset maskne. I hadn’t been pimple prone since my younger years, and didn’t seem to have issues with breakouts until covid went endemic. But I’m on immunosuppressants and work in a hotel in NYC. So, while sticking to masking, I got stuck with maskne. Enter differin. Yeah, I’d seen the ads, but I’m not a teen. I knew about retinoids and retinols but hadn’t used them. I wasn’t fighting aging, but was fighting sudden onset cystic acne, and losing the battle of absentmindedly picking and making them worse. It’s been 30 days. Top photo was at 3 weeks, bottom is 1 month. No makeup, no filter. I regret not taking a before photo, but I didn’t even want my phone to remember what a mess things were under that mask. By the end of the 1st week I started peeling. Week 2 I had every awful kind of pimple arise. Week 3 and I was about to give up. I guess I didn’t grasp how it gets worse before it gets better. (Was hoping for ‘it stays the same and then improves.’) Ugly, awful, uncomfortable, gross. And then seemingly overnight… voila! The texture of my skin has improved overall, and my husband who’s never seen me with acne before, was legit surprised by how soft my face is. New pimples don’t seem to be leaving behind dark spots as much. This stuff seems to make your pores puke out their guts and then peels it off like it never happened. I don’t have very sensitive skin and exfoliate regularly. I am legit excited for the summer now (with sunscreen of course!)
B**I
Amazing product
Background: 44 year old female with occasional breakouts sensitive to make-up and hormone fluctuations. I suffer some scaring to my chin and frown line area. Bought this double pack on a whim just to see if it could get my skin under control. When I bought it I had several areas on my face in different stages of healing and breakouts. I needed something to add to my skin care routine to keep these minimal but frequent breakouts under wraps. Manufacture states to give it 3 months to fully judge if it’s making a difference or not. I apply it once daily with a moisturizer and snail mucin. A pea size amount to my chin area and T-zone. I’m 2 weeks in and absolutely astonished at how well it took back my skin to the results I was hoping for. I have 0 breakouts and am hopeful it will help reduce the reddened areas that are still healing. I even made the mistake of sleeping in my make-up one night, woke up with an area that appeared was about to start a breakout. I washed my skin, applied the Differin adapalene and 24 hours later, no sign of a developing breakout. Skincare is so expensive, I’m so happy to know this is an affordable product I can keep in my regimen for a long time to come.
M**J
Couldn't see much improvement
Seemed like it might be helping but even after using for a month nothing that I could really see. My expectations may have been too high.
N**I
Work Effectively
Great
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